[صفحه اصلی ]   [Archive]  
:: صفحه اصلي :: درباره نشريه :: آخرين شماره :: تمام شماره‌ها :: جستجو :: ثبت نام :: ارسال مقاله :: تماس با ما ::
:: دوره 19، شماره 6 - ( 1399 ) ::
جلد 19 شماره 6 صفحات 2846-2864 برگشت به فهرست نسخه ها
Research Article: Expression differences of interferon regulatory factor 3 and non-specific cytotoxic cell receptor protein-1 in grass carp (Ctenopharyngodon idella) after challenges with two genotypes of grass carp reovirus, and analysis of antiviral signaling pathways
چکیده:   (597 مشاهده)
Grass carp reovirus (GCRV), with high genetic diversity, seriously affects grass carp farming. Meanwhile, interferon regulatory factor 3 (IRF3) and non-specific cytotoxic cell receptor protein-1 (NCCRP-1) play crucial roles in immunity system of fish. In this paper, we took IRF3 and NCCRP-1 as molecular markers in order to explore the differences in immune responses of grass carp infected with different GCRV strains, which is helpful in better understanding of the GCRV pathogenesity. Accordingly, we analyzed the expression differences of IRF3 and NCCRP-1 in grass carp after challenges with GCRV GD108 (genotype III) and GCRV 096 (genotype I) by qRT-PCR. We found IRF3 and NCCRP-1 was up-regulated in all tested tissues after challenges of GCRV GD108 and GCRV 096. However, the expression levels of IRF3 and NCCRP-1 depended on the GCRV strain, and the up-regulation changes were qualitatively similar but quantitatively different after challenges of GCRV GD108 and GCRV 096, that is, NCCRP-1 was up-regulated more, earlier, and more broadly than IRF3 after GCRV challenge. Besides, the NCCRP-1 was more rapidly up-regulated to a greater extent after challenges with GCRV 096 than GCRV GD108. In order to clarify whether the antiviral immune response and development of grass carp hemorrhage in grass carp differed depending on GCRV genotypes needs more investigation. Moreover, we speculated that the GCRV-induced signaling pathways in grass carp were enriched with measles- and influenza A-induced signaling pathways, and found 13 types of new genes in the GCRV-induced signaling pathway.
متن کامل [PDF 984 kb]   (178 دریافت)    
نوع مطالعه: پژوهشي | موضوع مقاله: fish disease
دریافت: 1397/2/4 | پذیرش: 1397/9/6 | انتشار: 1399/8/30
ارسال نظر درباره این مقاله
نام کاربری یا پست الکترونیک شما:

CAPTCHA


XML   English Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Yan X, Yan W, Chen M, Dai L, Jian J. Research Article: Expression differences of interferon regulatory factor 3 and non-specific cytotoxic cell receptor protein-1 in grass carp (Ctenopharyngodon idella) after challenges with two genotypes of grass carp reovirus, and analysis of antiviral signaling pathways. IJFS. 2020; 19 (6) :2846-2864
URL: http://jifro.ir/article-1-3406-fa.html

Research Article: Expression differences of interferon regulatory factor 3 and non-specific cytotoxic cell receptor protein-1 in grass carp (Ctenopharyngodon idella) after challenges with two genotypes of grass carp reovirus, and analysis of antiviral signaling pathways. مجله علوم شیلاتی ایران. 1399; 19 (6) :2846-2864

URL: http://jifro.ir/article-1-3406-fa.html



دوره 19، شماره 6 - ( 1399 ) برگشت به فهرست نسخه ها
Iranian Journal of Fisheries Sciences Iranian Journal of Fisheries Sciences
Persian site map - English site map - Created in 0.05 seconds with 30 queries by YEKTAWEB 4274