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Effects of letrozole, non-steroidal aromatase inhibitor, on serum sex steroid levels, oocyte diameter and gonadosomatic index (GSI) in rainbow trout (Oncorhynchus mykiss)
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چکیده: (6321 مشاهده) |
| The objective of this study was to contribute to investigate the efficacy of letrozole, a potent non-steroidal aromatase inhibitor, on serum sex steroid levels and oocyte growth in rainbow trout females. Serum steroid levels were measured using an indirect enzyme-linked immunosorbent assay (ELISA) before and 22 days after an initial injection with 1, 2.5 mg kg-1 and subsequent weekly injection with 2.5 mg kg-1letrozole. After the last blood collection, gonad tissues were removed and oocyte diameter and GSI were determined. In all groups treated with letrozole, serum 17β- esteradiol levels (E2) decreased significantly and inversely serum 17α-20ß dihydroxy-4 pregnen- 3- one (17α-20ß-P), testosterone(T) levels increased significantly from 6 to 96 h after injection (p<0.05). The lowest E2 levels, oocyte diameter and GSI were measured in the group treated weekly with 2.5 mg kg-1 letrozole (p<0.05). This study demonstrates that letrozole has the potential to interfere in the synthesis of endogenous estrogens from androgens and delay gonadal development. |
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متن کامل [PDF 296 kb]
(3630 دریافت)
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نوع مطالعه: پژوهشي |
موضوع مقاله:
Biology & physiology
دریافت: 1394/2/20 | پذیرش: 1394/2/20 | انتشار: 1394/2/20
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