[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit ::
Main Menu
Home::
Journal Information::
Articles archive::
Registration::
For Authors::
For Reviewers::
Contact us::
Site Facilities::
Webmail::
Publication Ethics::
::
Indexed & full text in

AWT IMAGE 

..
Journal's Impact Factor

 

             "If you have any questions or concerns, please contact us by email

 "ijfs.ifro(at)yahoo.com"

Journal`s Impact Factor 2023(Web of Science): 0.8 Q3
SJR 2023: 0.24 Q4
H Index (SJR): 29

Journal's Impact Factor ISC 2023: 0.32 Q1

 

..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Abstract in

 پایگاه استنادی علوم جهان اسلام (ISC)

پایگاه اطلاعات جهاد دانشگاهی (SID) 



بانک نشریات کشور (مگیران)


https://www.stomaeduj.com/wp-content/uploads/2019/12/publons.png





scholar.google

..

..
Journal DOI

AWT IMAGE
Journal DOI

10.18869/acadpub.ijfs
 

..
:: Volume 24, Issue 2 (2025) ::
IJFS 2025, 24 Back to browse issues page
Research Article: Phytochemical analysis, antioxidant, and anticancer activities of three brown algae from the Persian Gulf
A. Zarei-Ahmady *1 , M. Zare2 , M. Rashidi3 , A. Siahoosh4 , I. Nabiour5
1- 1Marine Pharmaceutical Science Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran & 2Department of Medicinal Chemistry, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran , zarei-a@ajums.ac.ir
2- 1Marine Pharmaceutical Science Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3- 3Department of Clinical Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4- 4Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5- 5The Persian Gulf Marine Biotechnology Research Center, the Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
Abstract:   (540 Views)
Marine seaweeds are sources of bioactive compounds such as novel anticancer components. This study investigated the phytochemical composition, antioxidant, and anticancer activities of aqueous and methanolic extracts of three brown algae (Sargassum obtusifolium, Padina gymnospora, and Cystoseira indica) from the Persian Gulf. The contents of total polyphenols, total flavonoids, and total carbohydrates were determined. The antioxidant activity of the extracts was determined by DPPH method. The cytotoxicity of extracts was evaluated using the MTT assay on breast cancer (MCF7) and lung cancer (A549) cell lines. The aqueous extracts had higher levels of polyphenols, flavonoids, and carbohydrates (ranging from 125±11 to 202±19 mg/g) than methanolic extracts (ranging from 43.8±3.4 to 76.6±6.9 mg/g). At 50 µg/mL, the inhibition of DPPH radical ranging from 40.9±0.6 to 62.3±1.4% with an IC50 ranged from 60.9±0.5 to 30.4±0.4 µg/mL. The MTT cell proliferation assay confirmed a significant reduction in MCF7 cell line viability in the methanolic extracts at 390 µg/mL and 190 µg/mL compared to the control group. The methanolic extract of S. obtusifolium showed the highest selectivity index on MCF7 and A549 cells (1.16±0.19 and 1.77±0.16 respectively), despite containing lower levels of phytochemicals than the aqueous extracts. The findings suggest that the methanolic extract of S. obtusifolium exhibits selective cytotoxicity against MCF7 cells. Also, the aqueous extract of C. indica shows an adequate antioxidant index, usable in nutritional science.
Keywords: Polyphenol, Flavonoid, Cytotoxicity, Selectivity index, MTT assay, Breast cancer
Full-Text [PDF 643 kb]   (247 Downloads)    
Type of Study: Orginal research papers | Subject: Biochemistry
ePublished: 2025/03/17
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Zarei-Ahmady A, zare M, Rashidi M, Siahoosh A, Nabiour I. Research Article: Phytochemical analysis, antioxidant, and anticancer activities of three brown algae from the Persian Gulf. IJFS 2025; 24 (2) :385-403
URL: http://jifro.ir/article-1-5767-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 24, Issue 2 (2025) Back to browse issues page
Iranian Journal of Fisheries Sciences Iranian Journal of Fisheries Sciences
Persian site map - English site map - Created in 0.06 seconds with 45 queries by YEKTAWEB 4710