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:: Volume 16, Number 3 (7-2017) ::
IJFS 2017, 16 Back to browse issues page
Histopathological evaluation of zebrafish (Danio rerio) larvae following embryonic exposure to MgO nanoparticles
M. Ghobadian *, M. Nabiuni, K. Parivar, M. Fathi, J. Pazooki
Abstract:   (104 Views)
The aim of this study was to investigate the histopathological changes in zebrafish larvae following embryonic exposure to nanoparticles of magnesium oxide (MgONPs). The toxicity of metal oxide nanoparticles is attracting increasing attention. Among these nanomaterials, MgONPs are particularly interesting as a low cost and environmentally-friendly material. Histological investigations are used as a highly sensitive method for detecting the morphological features of disease and abnormal gene function. We evaluated the histopathological changes in zebrafish larval tissues following embryonic exposure to MgONPs for a period of 4-96 h post fertilization (hpf). To this end; fixation, tissue processing, sectioning and general staining of the whole-larvae were performed. Histopathological evaluations showed some changes including psoriasis-like epithelial hyperproliferation, muscle cell degeneration, neurodegeneration in the spinal cord, swelling and edematous changes in pericardium, swelling and edematous changes in yolk sac, severe edema within the eyes, smaller retina, disruption of retinal lamination and impaired retinal differentiation. In summary, the results of this study enhance our understanding about the potential hazards of MgONPs to the environment.
Keywords: Zebrafish, MgO nanoparticles, Histopathology, Embryo
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Received: 2017/08/6 | Accepted: 2017/08/6 | Published: 2017/08/6
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Ghobadian M, Nabiuni M, Parivar K, Fathi M, Pazooki J. Histopathological evaluation of zebrafish (Danio rerio) larvae following embryonic exposure to MgO nanoparticles. IJFS. 2017; 16 (3) :959-969
URL: http://jifro.ir/article-1-2866-en.html
Volume 16, Number 3 (7-2017) Back to browse issues page
مجله علوم شیلاتی ایران Iranian Journal of Fisheries Sciences
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