en aquaculture aquaculture پژوهشي Orginal research papers <span lang="TR" style="font-size:11.0pt"><span calibri="" style="font-family:"><span style="color:black">&beta;-glucans (BG) are widely used as an immunostimulant in aquatic animals through injection, feed, and immersion. The present study aimed to examine the consequences of dietary administration of yeast &beta;-glucan on the immune response and susceptibility of <i>Macrobrachium rosenbergii</i> to the <i>Vibrio parahaemolyticus </i>infection. Experimental prawns (4.55&plusmn;0.08 g) were fed a formulated commercial diet supplemented with commercial yeast BG at 0.0% (control), 0.1% (T1), 0.2% (T2), and 0.3% (T3). After the feeding trial of 75 days, a challenge test with <i>V. parahaemolyticus </i>(10⁴ cfu/mL) was performed for seven days. No significant differences (<i>p</i>>0.05) were observed in terms of final weight, specific growth rate, and weight gain, but </span></span></span><span lang="TR" style="font-size:11.0pt"><span calibri="" style="font-family:"><span style="color:black">the prawns fed with 0.1% (T1) BG </span></span></span><span lang="TR" style="font-size:11.0pt"><span calibri="" style="font-family:"><span style="color:black">had the highest survival rates (100%). However, immune parameters, <i>e.g.</i> level of total hemolymph protein, albumin, globulin and hemocyte number, were found to be significantly higher (<i>p</i><0.05) in prawns fed with 0.2% (T2) BG-supplemented diet. The total hemocyte count and total hemolymph protein, albumin, and globulin were reduced after the <i>V. parahaemolyticus </i>infection.</span></span></span><span lang="TR" style="font-size:11.0pt"><span calibri="" style="font-family:"><span style="color:black"> The study&#39;s findings suggested that yeast BG can be used at 0.1% to 0.2% to enhance the immune response of juvenile <i>M. rosenbergii</i> and increase their resistance to <i>V. parahemolyticus</i> infection without upsetting the usual growth and survival.</span></span></span> ß-glucan, Macrobrachium rosenbergii, Immunostimulant, Immunity, Vibrio parahaemolyticus, Hemolymph 539 554 http://jifro.ir/browse.php?a_code=A-10-3759-2&slc_lang=en&sid=1 S.T. Rishan sakib.rishan71@gmail.com 100319475328460056743 100319475328460056743 No Bangladesh Agricultural University M.B. Hossen belalku@gmail.com 100319475328460056744 100319475328460056744 No Bangladesh Agricultural University M.R. Kibria kibria.rk55@gmail.com 100319475328460056745 100319475328460056745 No Bangladesh Agricultural University M.T. Hossain tofazzalmh@bau.edu.bd 100319475328460056746 100319475328460056746 No Bangladesh Agricultural University M.S. Alam samsul.alam@bau.edu.bd 100319475328460056747 100319475328460056747 Yes Bangladesh Agricultural University