en Biochemistry Biochemistry پژوهشي Orginal research papers <font face="Times New Roman" size="3"> </font><p class="MsoCommentText" style="margin: 0cm 0cm 0pt text-align: justify line-height: 120%"><font face="Times New Roman"><span lang="TR" style="line-height: 120% font-size: 12pt">The purpose of this study was </span><span lang="EN-GB" style="line-height: 120% font-size: 12pt mso-ansi-language: EN-GB">to investigate the therapeutic effects of natural products like propolis<b style="mso-bidi-font-weight: normal"> </b>on biochemical and hematologic parameters in carp (<i>Cyprinus carpio</i>, Linnaeus 1758) exposed to arsenic. </span><span lang="TR" style="line-height: 120% font-size: 12pt">In this study fish were</span><span lang="EN-GB" style="line-height: 120% font-size: 12pt mso-ansi-language: EN-GB"> exposed to 0.01 mg/L arsenic and 10 mg/L propolis for seven days. O</span><span lang="TR" style="line-height: 120% font-size: 12pt">ur results indicated that</span><span lang="TR" style="line-height: 120% font-size: 12pt mso-ansi-language: EN-GB"> </span><span lang="EN-GB" style="line-height: 120% font-size: 12pt mso-ansi-language: EN-GB">triglyceride, urea, total cholesterol, cobalt, ALT (<font size="3"><span class="minusone1"><span style="line-height: 120% mso-ansi-font-size: 12.0pt mso-bidi-font-size: 12.0pt">alanine amino transferase)</span></span>, AST (<span class="minusone1"><span style="line-height: 120% mso-ansi-font-size: 12.0pt mso-bidi-font-size: 12.0pt">aspartate amino transferase</span></span>), LDH (lactate dehydrogenase) values </font></span><span lang="TR" style="line-height: 120% font-size: 12pt">increased when exposed to arsenic </span><span lang="EN-GB" style="line-height: 120% font-size: 12pt mso-ansi-language: EN-GB">(</span><i style="mso-bidi-font-style: normal"><span lang="TR" style="line-height: 120% font-size: 12pt">P</span></i><span lang="TR" style="line-height: 120% font-size: 12pt"><0.05</span><span lang="EN-GB" style="line-height: 120% font-size: 12pt mso-ansi-language: EN-GB">) </span><span lang="TR" style="line-height: 120% font-size: 12pt">but reduced by combination of </span><span lang="EN-GB" style="line-height: 120% font-size: 12pt mso-ansi-language: EN-GB">arsenic and propolis (</span><i style="mso-bidi-font-style: normal"><span lang="TR" style="line-height: 120% font-size: 12pt">P</span></i><span lang="TR" style="line-height: 120% font-size: 12pt"><0.05</span><span lang="EN-GB" style="line-height: 120% font-size: 12pt mso-ansi-language: EN-GB">). Granulocyte, erythrocyte, hemoglobin, hematocrit values </span><span lang="TR" style="line-height: 120% font-size: 12pt">were </span><span lang="EN-GB" style="line-height: 120% font-size: 12pt mso-ansi-language: EN-GB">decreased</span><span lang="TR" style="line-height: 120% font-size: 12pt"> by use of </span><span lang="EN-GB" style="line-height: 120% font-size: 12pt mso-ansi-language: EN-GB">arsenic in comparison to control group. These parameters increased in arsenic+propolis group (</span><i style="mso-bidi-font-style: normal"><span lang="TR" style="line-height: 120% font-size: 12pt">P</span></i><span lang="TR" style="line-height: 120% font-size: 12pt"><0.05</span><span lang="EN-GB" style="line-height: 120% font-size: 12pt mso-ansi-language: EN-GB">). In addition levels of leucocyte, agranulocyte, MCV (mean corpuscular volume), MCH (mean corpuscular hemoglobin) and MCHC (mean corpuscular hemoglobin concentration) increased in the arsenic group (</span><i style="mso-bidi-font-style: normal"><span lang="TR" style="line-height: 120% font-size: 12pt">P</span></i><span lang="TR" style="line-height: 120% font-size: 12pt"><0.05</span><span lang="EN-GB" style="line-height: 120% font-size: 12pt mso-ansi-language: EN-GB">) </span><span lang="TR" style="line-height: 120% font-size: 12pt">and </span><span lang="EN-GB" style="line-height: 120% font-size: 12pt mso-ansi-language: EN-GB">decreased in arsenic+propolis group (</span><i style="mso-bidi-font-style: normal"><span lang="TR" style="line-height: 120% font-size: 12pt">P</span></i><span lang="TR" style="line-height: 120% font-size: 12pt"><0.05</span><span lang="EN-GB" style="line-height: 120% font-size: 12pt mso-ansi-language: EN-GB">). </span><span lang="TR" style="line-height: 120% font-size: 12pt">We can say that propolis can improve </span><span lang="EN-GB" style="line-height: 120% font-size: 12pt mso-ansi-language: EN-GB">biochemical and hematologic functions of common carp blood, after being exposed to arsenic.<o:p /></span></font></p><font face="Times New Roman" size="3"> </font> Antioxidant, Arsenic, Blood parameter, Cyprinus carpio, Hematological parameter, Propolis 405 414 http://jifro.ir/browse.php?a_code=A-10-1-166&slc_lang=en&sid=1 Z. Selamoglu Talas ztalas@nigde.edu.tr 10031947532846003236 10031947532846003236 Yes S. Pinar Dundar 10031947532846003237 10031947532846003237 No M. Fuat Gulhan 10031947532846003238 10031947532846003238 No I. Orun 10031947532846003239 10031947532846003239 No S. Kakoolaki 10031947532846003240 10031947532846003240 No