Iranian Journal of Fisheries Sciences
مجله علوم شیلاتی ایران
IJFS
Agriculture
http://jifro.ir
1
admin
1562-2916
10.18869/acadpub.ijfs
en
jalali
1401
8
1
gregorian
2022
11
1
21
6
online
1
fulltext
en
Research Article: The effect of Letrozole and Letrozole-Chitosan nanoparticles on masculinization of Rainbow trout larvae
(Oncorhynchus mykiss)
Genetics
Genetics
پژوهشي
Orginal research papers
<span style="font-size:11pt"><span style="line-height:120%"><span style="font-family:Calibri,sans-serif"><span lang="TR" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times=""><span style="color:black">This study aimed to investigate the efficiency of conjugating chitosan nanoparticles to letrozole (LET) on masculinization of rainbow trout larvae, <i>Oncorhynchus mykiss</i>. For this purpose, two treatments of LET, 1.5 and 3 mg/kg food, and two treatments of letrozole-chitosan nanoparticles (LET-CS), 0.5 and 1.5 mg/kg were performed with a control group. Treatments began immediately after active larval swimming and continued for 60 days. The results showed that the amount of testosterone during the trial increased significantly (<i>p</i><0.05), so that the highest amount of testosterone was observed in 3 mg/kg LET and 1.5 mg/kg LET-CS. However, estradiol was untraceable in all treatments. About 66.6, 73.33, 73.33, 76.66 and 43.33% males were observed in 1.5 mg/kg LET, 3 mg/kg LET, 0.5 mg/kg LET-CS, 1.5 mg/kg LET-CS and control, respectively. Despite the drug dosage in LET-CS treatments was half that of LET treatments, the sex ratio did not change among treatments (<i>p</i>≥ 0.05), which showed a positive effect of CS in effectiveness of LET. In general, it can be stated that using CS for the administration of LET could be effective in inhibiting the production of estradiol, increasing the amount of testosterone, and thus changing the sex ratio of rainbow trout.</span></span></span></span></span></span></span>
Aromatase inhibitor, Letrozole, Chitosan nanoparticles, Rainbow trout, Sex reversal
1383
1396
http://jifro.ir/browse.php?a_code=A-10-181-1&slc_lang=en&sid=1
H.
Alijani
mamini57@yahoo.com
100319475328460046590
100319475328460046590
No
Department of Fisheries, Faculty of Natural Resources, Behbahan Khatam Alanbia University of Technology, Behbahan, Iran
M.
Amini Chermahini
hassanalijani@gmail.com
100319475328460046591
100319475328460046591
Yes
Behbahan Khatam Alanbia University of Technology
D.
Zargham
davoodzargham61@gmail.com
100319475328460046592
100319475328460046592
No
Iranian Fisheries Science Research Institute
M.
Mohiseni
mohiseni@gmail.com
100319475328460046593
100319475328460046593
No
Lorestan University