en fish disease fish disease كاربردي Orginal research papers <p>Echinoderm diseases have attracted little interest in contrast to the other commercial marine organisms. This study reports the pathogenesis pattern of juvenile <em>Holothuria scabra. </em>11 pure bacteria were isolated from lesions of juvenile <em>H. scabra</em> with the symptoms of skin ulceration disease. Phylogenetic identification based on 16S rRNA gene sequences analysis revealed that they belonged to the genera <em>Arcobacter bivalviorum</em>, <em>Pseudoalteromonas citrea</em>, <em>Pseudoalteromonas </em>sp<em>.</em>, <em>Vibrio azureus</em>, <em>V. fortis, V. owensii, V.&nbsp; parahaemolyticus, V.&nbsp; rotiferianus, V. tubiashi </em>and <em>Vibrio </em>sp<em>.</em>.This study is the first report which find <em>V. owensii, V. azureus</em> and <em>V. fortis</em> as potential pathogens of holothuroids. All isolated bacteria showed <em>in vitro</em> susceptibility to the common antibiotics imipenem, chloramphenicol and amoxicillin/clavulanic acid. These antibiotics might be effective in reducing the incidence of the skin ulceration disease in case of emergency.</p> Pathogen, Skin ulceration, Vibrio, Sea cucumber, Beche-de-mer 915 923 http://jifro.ir/browse.php?a_code=A-10-2150-1&slc_lang=en&sid=1 Mehrnoush Tangestani mta147@uclive.ac.nz 100319475328460031032 100319475328460031032 Yes 1- Leibniz Centre for Tropical Marine Ecology GmbH, Fahrenheitstraße 6, Bremen 28359, Germany 2- Department of Chemical and Process Engineering, University of Canterbury, Christchurch 8041, New Zealand A Kunzmann 100319475328460031033 100319475328460031033 No Leibniz Centre for Tropical Marine Ecology GmbH, Fahrenheitstraße 6, Bremen 28359, Germany