en Biochemistry Biochemistry پژوهشي Orginal research papers Variations of lipid and fatty acid profile of <em>Perna viridis</em> and <em>Perna indica</em> were assessed from Kanyakumari district.&nbsp; Lipid compositions varied and were measured as 8.92&plusmn;0.03% in <em>P. viridis</em> and 6.73&plusmn;0.01% in <em>P. indica</em>. The percentage composition of individual fatty acids as a ratio of total muscle lipids of <em>P. viridis</em> ranged from 0.11&plusmn;0.01% to 25.09&plusmn;0.03% whereas in <em>P</em><em>. indica</em> it ranged from 0.10&plusmn;0.01% to 33.2&plusmn;0.05%.&nbsp; Highest proportions of fatty acids were of palmitic acid which was present in both species. The ratio of Omega-3 and Omega-6 fatty acids was 0.35&plusmn;0.05 - 3.09&plusmn;0.04 in <em>P. viridis</em> while in <em>P. indica</em> it was less than 1. Both the mussel species contained essential fatty acids particularly eicosapentaenoic acid and docosahexaenoic acid for promoting good health, as well as prevention and healing of diseases in humans. <em>P. viridis</em> and <em>P. indica</em> were recommended for human beings due to the presence of high content of unsaturated fatty acids.&nbsp; Perna viridis, Perna indica, Lipid, Fatty acid profile. 761 772 http://jifro.ir/browse.php?a_code=A-10-1805-1&slc_lang=en&sid=1 M. Dalin dalinbosco@gmail.com 100319475328460039486 100319475328460039486 Yes St.Jude’s College, Thoothoor, Tamil Nadu, India K. Saritha saritha23kailasam@gmail.com 100319475328460039487 100319475328460039487 No SDMRI, 44 - Beach road, tuticorin, 628001 J. Patterson jamilapat@gmail.com 100319475328460039488 100319475328460039488 No bSuganthi Devadason Marine Research Institute, Tuticorin, Tamil Nadu, India