en aquaculture aquaculture پژوهشي Orginal research papers <span style="font-size:11pt"><span style="line-height:120%"><span style="tab-stops:28.35pt"><span style="text-autospace:ideograph-numeric"><span style="font-family:Calibri,sans-serif"><span lang="TR" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times=""><span style="color:black">The predatory <i>Bdellovibrio</i> is considered one of the most promising probiotics in aquaculture. Yet the effect of dietary <i>Bdellovibrio</i> probiotics on Chinese mitten crab <i>Eriocheir sinensis</i> has never been evaluated. In the present study, a fifty-day feeding trial was conducted to assess the effects of dietary <i>Bdellovibrio</i> powder at a recommended final dose of 7.5 g kg^-1 diets on non-specific immunity, antioxidant ability and disease resistance of <i>E. sinensis</i>. The results indicated that compared with the control, the activities of lysozyme, superoxide dismutase, catalase, acid phosphatase, and alkaline phosphatase were significantly increased in the serum and hepatopancreas of <i>E. sinensis</i> fed with <i>Bdellovibrio</i> powder-supplemented diets (<i>p</i><0.05). Besides, a significant reduction of malondialdehyde level was also observed in the serum and hepatopancreas of <i>Bdellovibrio</i> powder-fed<i> </i>crabs (<i>p</i><0.05). In addition, the test crabs fed diets<i> </i>with <i>Bdellovibrio</i> powder for fifty days exhibited significantly (<i>p</i><0.05) higher protection against aeromonasis, showing a relative percentage survival of 81.25% against <i>Aeromonas veronii</i> challenge for seven days. To conclude, dietary supplementation of <i>Bdellovibrio</i> powder for fifty days can increase immunity, antioxidant capability and resistance of <i>E. sinensis</i> to <i>A. veronii</i> infection. </span></span></span></span></span></span></span></span></span> Antioxidant ability, Bdellovibrio powder, Disease resistance, Eriocheir sinensis, Non-specific immunity 948 965 http://jifro.ir/browse.php?a_code=A-10-4362-1&slc_lang=en&sid=1 J. Liu 1484317187@qq.com 100319475328460046458 100319475328460046458 No National Pathogen Collection Center for Aquatic Animals, Shanghai Engineering Research Center of Aquaculture, Shanghai Ocean University, Shanghai 201306, China. J. Li 1404781896@qq.com 100319475328460046459 100319475328460046459 No National Pathogen Collection Center for Aquatic Animals, Shanghai Engineering Research Center of Aquaculture, Shanghai Ocean University, Shanghai 201306, China. X. Huang 990592642@qq.com 100319475328460046460 100319475328460046460 No National Pathogen Collection Center for Aquatic Animals, Shanghai Engineering Research Center of Aquaculture, Shanghai Ocean University, Shanghai 201306, China. B. Chen 165485663@qq.com 100319475328460046461 100319475328460046461 No Lianyungang Marine and Fisheries Development Promotion Center, Lianyungang Jiangsu 222000, China. J. An 599699775@qq.com 100319475328460046462 100319475328460046462 No Lianyungang Marine and Fisheries Development Promotion Center, Lianyungang Jiangsu 222000, China. H. Cao hpcao@shou.edu.cn 100319475328460046463 100319475328460046463 Yes National Pathogen Collection Center for Aquatic Animals, Shanghai Engineering Research Center of Aquaculture, Shanghai Ocean University, Shanghai 201306, China.