Iranian Journal of Fisheries Sciences
مجله علوم شیلاتی ایران
IJFS
Agriculture
http://jifro.ir
1
admin
1562-2916
10.18869/acadpub.ijfs
en
jalali
1395
1
1
gregorian
2016
4
1
15
2
online
1
fulltext
en
Evaluation of pre-clinical safety and toxicology of Althaea officinalis extracts as naturopathic medicine for common carp (Cyprinus carpio)
Toxicology
Toxicology
پژوهشي
Orginal research papers
<p dir="ltr" style="text-align: justify;">The current study was done to investigate the preclinical safety and toxicology of <em>Althaea officinalis</em> extract as naturopathic medicine in common carp (<em>Cyprinus carpio</em>). Specimens were treated with 0 (control), 2.5, 5 and 10 g of marshmallow extract for 45 days. Plasma biochemical parameters were measured after 15 and 45 days. Total protein, albumin and globulin levels (<em>p</em><0.05) were significantly higher in the fish fed with 10 g <em>A. officinalis</em> extract than that in control groups on day 45. Although, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities significantly decreased (<em>p</em><0.05) in fish fed with <em>A. officinalis</em> extract on day 15. The use of the <em>A. officinalis</em> extract (10 g) led to a significant increase in AST, lactate dehydrogenase (LDH) and ALP activities and cholesterol levels on day 45 (<em>p</em><0.05)<a name="OLE_LINK49"></a><a name="OLE_LINK46"> and a significant </a>decrease in plasma glucose and cholesterol levels on day 15 (<em>p</em><0.05). There was no significant difference in glucose levels and creatine kinase (CK) activity between all treatments and the control group on day 45 (<em>p</em>>0.05). During the experimental period, triglyceride levels noticeably decreased in fish fed with 2.5 g of <em>A. officinalis</em> extract (<em>p</em><0.05). Although, administration of marshmallow extract up to 5 g per kg of feed did not show any side effect on fishes, the use of the <em>A. officinalis</em> extract (10 g) led to cytotoxicity and modifications in blood biochemical parameters of fish. Therefore, we recommend the use of the lower concentrations than 10 g <em>A. officinalis</em> extract in prospective clinical studies. </p>
Biochemical parameters, Common carp, Marshmallow, Medicinal plants, pre-clinical study
613
629
http://jifro.ir/browse.php?a_code=A-10-1272-190&slc_lang=en&sid=1
V.
Soleimany
100319475328460016604
100319475328460016604
No
M.
Banaee
mahdibanaee@yahoo.com
100319475328460016605
100319475328460016605
Yes
M.
Mohiseni
100319475328460016606
100319475328460016606
No
B.
Nematdoost Hagi
100319475328460016607
100319475328460016607
No
L.
Mousavi Dehmourdi
100319475328460016608
100319475328460016608
No