Mnemiopsis leidyi which was accidentally introduced into the Caspian Sea in 1999 and since then has colonized extensively. The horizontal distribution of M. leidyi and dominant mesozooplankton species was investigated in the south western Caspian Sea during February, May, July and November 2008. The average number and biomass of M. leidyi were in the same range (ca 200 individuals^.m^-3 (2000 ind^.m^-2) and 16 g wet weight^.m^-3 (180 g^.m^-2) in comparison with previous surveys. As in previous years the population consisted mainly of individuals <1 cm. The decline in mesozooplankton species observed since 1996 continued in 2008. Only two species of the previously recorded 24 Cladocera species were found in 2008. Of five Copepoda species recorded in 1996, only one, Acartia tonsa, was found in 2008 and even here adult individuals have reduced 3-fold since 1996. Bivalve larvae have declined by one order of magnitude since 1996. Among the dominant species, only the numbers of Cirripedia larvae and in part the numbers of Pleopis polyphemoides (Cladocera) were in the same range as in 1996.