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:: دوره 10، شماره 3 - ( 1390 ) ::
جلد 10 شماره 3 صفحات 487-496 برگشت به فهرست نسخه ها
In vitro effect of Nanosilver toxicity on fibroblast and mesenchymal stem cell lines
چکیده:   (11542 مشاهده)

 Nanotechnology presents countless opportunities to develop new and improved consumer products for the benefit of the society . A most prominent nanoproduct is nanosilver. Nanosilver particles are generally smaller than 100 nm and contain 20–15,000 silver atoms. Despite the wide application of nanomaterials, there is a serious lack of information concerning their impact on human health. In the previous study we reported the cytotoxic of nanosilver on osteoblast G292 cancer cell line and the amount of IC50 determined as 3.42 µg/ml (Moaddab et al., Iran. Nano Lett., Vol. 1, No. 1, January 2011, pp. 11-16). The purpose of the present study is to assess the biological assay of nanosilver on two normal cell lines of fibroblast (HF2), and mesenchymal stem cells . The effect of nanosilver on these cells is evaluated by light microscopy, and by cell proliferation and standard cytotoxicity assays. The results demonstrate a concentration-dependent toxicity for the cells tested, and IC50 was determined as 6.33, and 6.68 µg/ml in mesenchymal stem cell, and fibroblast HF2, respectively. There is no significant difference between the 24 h and 48 h of cells exposure to nanosilver. The results show that Nano-Ag possesses low toxicity to normal cells and can display potential application in cancer chemoprevention and chemotherapy.

     
نوع مطالعه: پژوهشي | موضوع مقاله: Biology & physiology
دریافت: ۱۳۹۰/۵/۲۹ | پذیرش: ۱۳۹۴/۶/۲۲ | انتشار: ۱۳۹۴/۶/۲۲
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Shahbazzadeh D, Ahari H, Motalebi A A, Anvar A A, Moaddab S, Asadi T, et al . In vitro effect of Nanosilver toxicity on fibroblast and mesenchymal stem cell lines. IJFS. 2011; 10 (3) :487-496
URL: http://jifro.ir/article-1-220-fa.html

In vitro effect of Nanosilver toxicity on fibroblast and mesenchymal stem cell lines. مجله علوم شیلاتی ایران. 1390; 10 (3) :487-496

URL: http://jifro.ir/article-1-220-fa.html



دوره 10، شماره 3 - ( 1390 ) برگشت به فهرست نسخه ها
مجله علوم شیلاتی ایران Iranian Journal of Fisheries Sciences
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