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:: Volume 14, Issue 1 (1-2015) ::
IJFS 2015, 14 Back to browse issues page
Effects of letrozole, non-steroidal aromatase inhibitor, on serum sex steroid levels, oocyte diameter and gonadosomatic index (GSI) in rainbow trout (Oncorhynchus mykiss)
P Akbary * , A Mirvaghefi , M Akhlaghi , B Majazi Amiri
, paria.akbary@gmail.com
Abstract:   (2787 Views)
The objective of this study was to contribute to investigate the efficacy of letrozole, a potent non-steroidal aromatase inhibitor, on serum sex steroid levels and oocyte growth in rainbow trout females. Serum steroid levels were measured using an indirect enzyme-linked immunosorbent assay (ELISA) before and 22 days after an initial injection with 1, 2.5 mg kg-1 and subsequent weekly injection with 2.5 mg kg-1letrozole. After the last blood collection, gonad tissues were removed and oocyte diameter and GSI were determined. In all groups treated with letrozole, serum 17β- esteradiol levels (E2) decreased significantly and inversely serum 17α-20ß dihydroxy-4 pregnen- 3- one (17α-20ß-P), testosterone(T) levels increased significantly from 6 to 96 h after injection (p<0.05). The lowest E2 levels, oocyte diameter and GSI were measured in the group treated weekly with 2.5 mg kg-1 letrozole (p<0.05). This study demonstrates that letrozole has the potential to interfere in the synthesis of endogenous estrogens from androgens and delay gonadal development.
Keywords: Aromatase inhibitor, Sex steroid, GSI, Oncorhynchus mykiss
Full-Text [PDF 296 kb]   (1471 Downloads)    
Type of Study: Orginal research papers | Subject: Biology & physiology
Received: 2015/05/10 | Accepted: 2015/05/10 | Published: 2015/05/10
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Akbary P, Mirvaghefi A, Akhlaghi M, Majazi Amiri B. Effects of letrozole, non-steroidal aromatase inhibitor, on serum sex steroid levels, oocyte diameter and gonadosomatic index (GSI) in rainbow trout (Oncorhynchus mykiss). IJFS. 2015; 14 (1) :289-301
URL: http://jifro.ir/article-1-1865-en.html


Volume 14, Issue 1 (1-2015) Back to browse issues page
مجله علوم شیلاتی ایران Iranian Journal of Fisheries Sciences
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