en aquaculture aquaculture پژوهشي Orginal research papers <span style="font-size:11pt"><span style="line-height:120%"><span style="text-autospace:none"><span style="font-family:Calibri,sans-serif"><span lang="TR" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times="">In the present study selenium nanoparticles (Se-NPs) and zinc nanoparticles (Zn-NPs) included in the diets of white shrimp at 0 mg (control), </span></span></span><span lang="TR" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times="">0.3 mg Se-NPs/ kg feed (T1</span></span></span><span lang="TR" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times="">)</span></span></span><span lang="TR" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times="">, 0.15 mg Se-NPs+15 mg Zn-NPs/kg feed (T2</span></span></span><span lang="TR" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times="">) </span></span></span><span lang="TR" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times="">and 30 mg Zn-NPs/kg feed (T3</span></span></span><span lang="TR" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times="">)</span></span></span><span lang="TR" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times="">. After 8 weeks, shrimps fed both Se-NPs and Zn-NPs showed higher (<i>p</i></span></span></span><span lang="TR" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times=""><0.05) final body weigh, weigh gain, and SGR than shrimp fed the control diet. On the other hand, the FCR was decreased by Se-NPs and Zn-NPs when compared to the control whereas both Se-NPs+Zn-NPs revealed lower FCR than the other groups (<i>p</i><0.05). Shrimp fed Se-NPs or Se-NPs +Zn-NPs revealed higher survival rate than shrimp fed the control and Zn-NPs while shrimp fed Zn-NPs showed higher survival rate than shrimp fed the control (<i>p</i><0.05). The total haemocyte count, large granular cells, <span style="background:white"><span style="color:black">semi granular cells, and semi granular cells </span></span>revealed higher counts in shrimps fed Se-NPs and Zn-NPs than the control (<i>p</i><0.05). Shrimp fed Se-NPs or Se-NPs+ Zn-NPs revealed higher </span></span></span><span lang="EN-GB" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times="">catalase (</span></span></span><span lang="TR" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times="">CAT), superoxide dismutase (SOD), and glutathione peroxidas (GPX) activities than shrimp fed the control and Zn-NPs while shrimp fed Zn-NPs showed higher catalase activity than shrimp fed the control (<i>P</i></span></span></span><span lang="TR" style="font-size:12.0pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times=""><0.05). The total protein, lysozyme, and phenoloxidase activities increased in shrimp fed Se-NPs or/and Zn-NPs with the highest being in shrimp fed both in shrimp fed Se-NPs and Zn-NPs followed by those fed Se-NPs then Zn-NPs when compare to the control (<i>p</i><0.05). In conclusion, the co supplementation of Se-NPs and Zn-NPs showed higher performances, antioxidant status, and immune responses in white shrimp than the individual supplementation of Se-NPs or Zn-NPs.</span></span></span></span></span></span></span> Litopenaeus vannamei, Zinc, Selenium, Growth, Immunity, Antioxidant 1125 1140 http://jifro.ir/browse.php?a_code=A-10-3653-2&slc_lang=en&sid=1 M. Karamzadeh milad.karamzadeh@yahoo.com 100319475328460046502 100319475328460046502 No Department of Fisheries, Bandar Abbas Branch, Islamic Azad University, Bandar Abbas, Iran M. Yahyavi maziar_yahyavi@yahoo.com 100319475328460046503 100319475328460046503 Yes Department of Fisheries, Bandar Abbas Branch, Islamic Azad University, Bandar Abbas, Iran A.R. Salarzadeh reza1375bandar@yahoo.com 100319475328460046504 100319475328460046504 No Department of Fisheries, Bandar Abbas Branch, Islamic Azad University, Bandar Abbas, Iran D. Nokhbe Zare delaram.zare@gmail.com 100319475328460046505 100319475328460046505 No Department of Fisheries, Bandar Abbas Branch, Islamic Azad University, Bandar Abbas, Iran